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Cell CAT Scans -

An interview with Dr. Carolyn Larabell of the National Center for X-ray Tomography. Dr. Biology learns about the new microscope being developed to see inside cells in a way never before possible.

Podcast content summary and time log for Volume 26 of Ask-a-Biologist.


Dr. Carolyn Larabell poses with an
an early image of a yeast cell
 made by the X1 microscope.


Keywords and topics that are found in this program: cells, x-rays, tomography, microscope, synchrotron.

Topic Time
Introduction - driving to the synchrotron 00:00
Why are the microscopes called X1 and XM2? 03:06
Micronauts - study inner space 03:32
Journey inside a cell - take a tour of the parts of a cell 03:59
Plasma Membrane 04:43
Membrane Channels 05:00
Cytoplasm 05:42
Cytoskeleton 06:03
Nucleus - DNA 06:33
Nuclear Pores 07:20
Transcription and Messenger RNA 07:34
Endoplasmic Reticulum (E.R.) 08:04
Ribosome's and proteins 08:16
Rough E.R. 08:47
Proteins 09:03
Organelles - literally tiny organs 09:27
Golgi apparatus 09:50
Mitochondria - ATP 10:21
Organelle trivia - Why is Golgi capitalized? 11:20
How things move and are transported around the cell 11:39
A view of the synchrotron from above 12:25
Why are synchrotrons round? 13:16
Hard and soft X-rays 13:47
How do you see cells if they are transparent? [labeling cells] 14:53
Walking to the XM2 microscope lab 15:37
What and why do you need a vacuum for particle accelerators? 16:35
What does tomography mean? 17:05
Example of how tomography is used today. [CAT scans] 17:58
Entering the laboratory - description of the microscope. 18:37
Description of the microscope. 19:17
Can any cells be placed in the microscope and do you have to do anything special to the cells? [freezing] 20:20
Viewing an image of a cell from the XM2 - Skittles? 21:28
What can we do with this new microscope? 23:15
Drug trafficking 23:39
Cancer treatment research 24:10
How was the microscope designed and built? 24:49
How long did it take to build the microscope? 25:21
More details on the look of the microscope 25:53
Importance of collaboration in large projects. 27:08
When did you first know you wanted to be a biologist? 28:10
What would you do if you were not a biologist? 29:03
What advice do you have for someone interested in being a biologist? 29:44
Sign-off 31:06

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