School of Life Sciences | Ask A Biologist

dropdown arrow downdropdown arrow upshow/hide menu

Ask A Biologist graphic

Receptors and Cell Surface Markers

show/hide words to know

  • Antibody: a molecule made by B-cells to trap foreign particles and microbes... more
  • Antigen: a molecule that can be recognized by the immune system... more
  • Bacteria: one-celled, microscopic organisms that grow and multiply everywhere on Earth. They can be either useful or harmful to animals... more
  • Cytokine: a chemical released by cells in the immune system that helps coordinate an immune response by sending messages to specific cells... more
  • Immune system: all the cells, tissues, and organs involved in fighting infection or disease in the body... more
  • Microbe: a living thing so tiny that you would need a microscope to see it... more
  • Receptor: a molecule on the surface of a cell that receives signals from specific molecules.

arrow left back to comic

Friend or foe? Identifying invaders and bandits

The human body has the ability to recognize millions of different enemies. Our built-in “defense force” is called the immune system. Different parts of the system can produce cells and powerful chemicals called cytokines. These cells and cytokines match up with and destroy bacteria and other invaders. Millions and millions of immune system cells are organized into sets and subsets. These groups of cells pass information back and forth.

The chemical substances produced by these cells function as an internal alarm system. Their message is simple: “Germs are here. Kill the germs.”

cytokines vs bacteriaThe immune system does much more than simply protect us from infection. It can tell the difference between the body's own cells and those belonging to invaders. Immune system cells can tell the difference between “self” and “non-self.”

receptorsEach and every cell in our body carries special marker molecules. These markers are also called antigens. They advertise “self.” Think of a typical cell as being an orange covered with knobby toothpicks and colorful little marker flags.

On a real cell, these toothpicks and flags are bits of protein and other special molecules. One or more of these bits of protein tell the immune system's hunter and killer cells that everything is fine. The alarm sounds when immune defenders come across a cell or microbe that has no “self” marker. The system swings into action to meet the threat of disease.

Long-term memory

antibodiesImmune system cells can remember past fights with disease-causing viruses and bacteria. The system keeps a chemical record of how it recognized each invader. These special protein molecules are called antibodies. Antibodies are Y-shaped molecules. They fit a specific antigen much like a key fits into a lock. Any cell or organism that triggers the immune system into action is called an antigen (and is usually a non-self antigen). Antigens can be germs such as a virus or bacterium. Or they can be bits and pieces of those germs.

Antibodies lock onto an antigen. They serve as the flag that marks the invader for destruction. Later, when a similar microbe invades again, the body recognizes it as an invader. The immune system cranks into action. The goal is to destroy the invading antigen or microbe before it can develop into a new infection.

This is why most people get chicken pox or other childhood diseases only once. The immune system fought the fight once against these invading germs. Vaccines work the same way. They expose your body to pieces or weakened versions of the germs, and your body learns to fight them off. Vaccines for measles and mumps help children avoid getting the disease at all. Your body keeps a chemical record and protects you from contracting those illnesses.

To learn more about your body's immune system, visit Viral Attack.

arrow left back to comic


Additional images from Wikimedia via ArturoJuárezFlores (T-cell).

cell receptor

An image of a T-cell, which plays an important part in the immune system.

book icon” title=“book icon Microbes

Story Behind the Scenes

 

For Teachers

Download comic as PDF packet
or
Get a MagCloud version for print or iPad

Share to Google Classroom

Be part of Ask A Biologist

by volunteering, or simply sending us feedback on the site. Scientists, teachers, writers, illustrators, and translators are all important to the program. If you are interested in helping with the website we have a Volunteer page to get the process started.

dropdown arrow downdropdown arrow up  Learn More

cell receptor

An image of a T-cell, which plays an important part in the immune system.

book icon” title=“book icon Microbes

Story Behind the Scenes

 

For Teachers

Download comic as PDF packet
or
Get a MagCloud version for print or iPad

Share to Google Classroom

Be part of Ask A Biologist

by volunteering, or simply sending us feedback on the site. Scientists, teachers, writers, illustrators, and translators are all important to the program. If you are interested in helping with the website we have a Volunteer page to get the process started.